HIV感染与系统性红斑狼疮：它们的致病关系。
HIV infection and SLE: their pathogenic relationship.
作者信息
Sekigawa I, Kaneko H, Hishikawa T, Hashimoto H, Hirose S, Kaneko Y, Maruyama N
机构信息
Department of Medicine, Juntendo University, Izu-Nagaoka Hospital, Shizuoka, Japan.
出版信息
Clin Exp Rheumatol. 1998 Mar-Apr;16(2):175-80.
PMID:9536396
Abstract
Retroviruses have repeatedly been suggested as a possible trigger mechanism for systemic lupus erythematosus (SLE). We review the role of human immunodeficiency virus (HIV)-1 envelope glycoprotein (gp120) in the induction of immune dysregulation including autoimmunity in HIV-1 infection, and discuss the possible relationship between HIV and SLE in the retroviral etiology.
摘要
逆转录病毒一再被认为是系统性红斑狼疮（SLE）可能的触发机制。我们综述了人类免疫缺陷病毒1型（HIV-1）包膜糖蛋白（gp120）在HIV-1感染中诱导包括自身免疫在内的免疫失调的作用，并讨论了在逆转录病毒病因学中HIV与SLE之间的可能关系。
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