Effect of edifenphos on follicular dynamics in albino rats.

Exposure of rats to 0.1, 0.15 and 0.20 mg/100 g body weight edifenphos (i.p.) had no significant effect on the number of healthy follicles and atretic follicles in all the stages. However, treatment with 0.25 mg dose resulted in a significant decrease in stage I and total number of healthy follicles and increase in stage V atretic follicles. A significant decrease in stage I, II, III and total number of healthy follicles, and a significant increase in stage I, III, IV and total number of atretic follicles were observed in 0.3 mg edifenphos treated rats. The results indicate that the effect of edifenphos is dose dependent.