接受容量扩充的早产儿的中心-外周温差、血压和精氨酸加压素
Central-peripheral temperature difference, blood pressure, and arginine vasopressin in preterm neonates undergoing volume expansion.
作者信息
Lambert H J, Baylis P H, Coulthard M G
机构信息
Department of Child Health, University of Newcastle upon Tyne.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1998 Jan;78(1):F43-5. doi: 10.1136/fn.78.1.f43.
AIM
To examine the effect of intravascular volume expansion for the treatment of hypovolaemia in sick preterm neonates.
METHODS
An intravenous infusion of 20 ml per kg of 4.5% albumin was given to 14 preterm neonates. The effects on systolic blood pressure, central peripheral temperature difference (c-pT), and plasma arginine vasopressin concentration (pAVP) were measured.
RESULTS
Thirteen babies showed a rise in systolic blood pressure. The six babies with the highest initial values of pAVP and c-pT showed a fall in both of these after infusion. The babies with lower initial pAVP (below 4 pmol/l) showed either a rise (two) or no change (six) after albumin infusion. There was a significant correlation between c-pT and log pAVP before (r2 = 0.61; p < 0.05) and after infusion (r2 = 0.45; p < 0.05).
CONCLUSIONS
Plasma AVP concentration is related to c-pT in unwell preterm newborns. This study suggests that clinical assessment of hypovolaemia in preterm newborns is poor and could be improved by using c-pT.
目的
探讨血管内容量扩充对患病早产儿低血容量的治疗效果。
方法
对14例早产儿静脉输注每千克20毫升的4.5%白蛋白。测量其对收缩压、中心外周温差（c-pT）和血浆精氨酸加压素浓度（pAVP）的影响。
结果
13例婴儿收缩压升高。pAVP和c-pT初始值最高的6例婴儿输注后这两项指标均下降。初始pAVP较低（低于4 pmol/l）的婴儿输注白蛋白后，2例升高，6例无变化。输注前c-pT与log pAVP之间（r2 = 0.61；p < 0.05）以及输注后（r2 = 0.45；p < 0.05）存在显著相关性。
结论
不适的早产新生儿血浆AVP浓度与c-pT相关。本研究表明，早产新生儿低血容量的临床评估较差，使用c-pT可改善评估。
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