Lambert H J, Baylis P H, McAulay J A, Coulthard M C
Department of Child Health, University of Newcastle upon Tyne.
Arch Dis Child Fetal Neonatal Ed. 1998 Jan;78(1):F38-42. doi: 10.1136/fn.78.1.f38.
To examine the effect of intermittent positive pressure ventilation (IPPV) on plasma arginine vasopressin concentration (pAVP) in preterm neonates.
Thirty five neonates were classified, at the time of blood sampling, into three groups: unstable ventilated; stable ventilated; and stable non-ventilated. A modification of an extraction method for pAVP was developed for use in studies on very small babies, and sampling methods were compared.
The pAVP (median, range) was similar in the ventilated (1.85 pmol/l, 0.5 to 3.4) and non-ventilated (2.0, 0.5 to 2.6) stable babies, but was significantly higher (5.7, 1.1 to 25) in the unstable group. There was an inverse correlation between systolic blood pressure and pAVP concentration.
This study shows that in preterm neonates pAVP concentration is affected by the clinical condition and blood pressure, but not by treatment with IPPV.
研究间歇性正压通气（IPPV）对早产儿血浆精氨酸加压素浓度（pAVP）的影响。
在采血时，将35例新生儿分为三组：通气不稳定组；通气稳定组；未通气稳定组。开发了一种用于极小小儿研究的pAVP提取方法，并对采样方法进行了比较。
通气稳定组（1.85 pmol/l，0.5至3.4）和未通气稳定组（2.0，0.5至2.6）的pAVP（中位数，范围）相似，但不稳定组显著更高（5.7，1.1至25）。收缩压与pAVP浓度呈负相关。
本研究表明，早产儿的pAVP浓度受临床状况和血压影响，但不受IPPV治疗影响。
