Kim S H, Moon Y S, Keller W L, Park C S
Department of Oncology/Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Br J Nutr. 1998 Feb;79(2):177-83. doi: 10.1079/bjn19980029.
The proper use of a time-dependent and controlled nutrition regimen during the hormone-sensitive growth phase before first parturition can significantly affect mammary growth and subsequent lactation performance. The objective of the present study was to determine if a compensatory nutrition regimen improves lactation performance by affecting proliferation and apoptosis of mammary epithelial cells. Forty female rats (7 weeks of age, average weight 148 g) were assigned to either (1) control, free access to diet or (2) stair-step compensatory nutrition regimen, an alternating 3-4-week schedule beginning with an energy-restricted diet (31.2% restriction) for 3 weeks, followed by the control diet for 4 weeks. Estimated milk yield was greater (P < 0.05) on day 15 of lactation in the compensatory nutrition group than in the control group. Mammary cell proliferation values were 1.4- and 2.7-fold greater in mammary tissue from the compensatory group during pregnant and early lactating stages respectively, compared with those from the control group. Ornithine decarboxylase (EC 4.1.17) mRNA was 24% higher (P < 0.05) in mammary tissues of rats from the compensatory nutrition group during pregnancy than in those from the control group. These results indicate that the compensatory nutrition regimen imposed during the peripubertal growth phase stimulated mammary epithelial cell proliferation and improved lactation performance.
在首次分娩前激素敏感的生长阶段，合理使用时间依赖性且可控的营养方案可显著影响乳腺生长及随后的泌乳性能。本研究的目的是确定补偿性营养方案是否通过影响乳腺上皮细胞的增殖和凋亡来改善泌乳性能。将40只雌性大鼠（7周龄，平均体重148克）分为两组：（1）对照组，自由进食；（2）阶梯式补偿性营养方案组，采用交替的3 - 4周时间表，开始为能量限制饮食（限制31.2%）3周，随后为对照饮食4周。泌乳第15天时，补偿性营养组的估计产奶量高于对照组（P < 0.05）。与对照组相比，补偿组妊娠和泌乳早期乳腺组织中的乳腺细胞增殖值分别高出1.4倍和2.7倍。补偿性营养组大鼠妊娠期间乳腺组织中的鸟氨酸脱羧酶（EC 4.1.17）mRNA比对照组高24%（P < 0.05）。这些结果表明，青春期生长阶段实施的补偿性营养方案刺激了乳腺上皮细胞增殖并改善了泌乳性能。
