Heyworth P, Morlet N, Rayner S, Hykin P, Dart J
Moorfields Eye Hospital, London.
Br J Ophthalmol. 1998 Jan;82(1):26-8. doi: 10.1136/bjo.82.1.26.
AIMS/BACKGROUND: Recurrent erosion syndrome encompasses a group of mixed aetiologies for which there are a number of methods of management which may influence the course of the disease.
The outcomes of a cohort of patients initially treated with topical lubricants were studied. 117 consecutive patients presenting over 1 year with a history of recurrent erosions were enrolled, baseline characteristics were documented, and treatment with lubricants was initiated. Patients were surveyed 4 years later inquiring about symptoms and treatments required.
A total of 94 (80%) of the initial cohort were contacted. The mean age was 44 years and the sex distribution was 44 males to 50 females. The mean period of follow up was 48 months. 55 (59%) were still symptomatic with attacks occurring at a median frequency of 60 days. 13 patients (24%) complained of an episode at least every week and 28 patients (51%) suffered at least every month. The median pain score (analogue scale of 1-10) was 2.5. Seventy five per cent (n = 21) of patients with epithelial basement membrane dystrophy (EBMD) were symptomatic compared with those with a traumatic aetiology among whom 46% (n = 28) were symptomatic. This difference was significant (p = 0.02). Those with EBMD were more likely to be continuing to use topical lubricants than the trauma group.
Patients with a traumatic aetiology are less likely to suffer chronic recurrent erosion syndrome than those with EBMD.
目的/背景：复发性糜烂综合征病因多样，有多种治疗方法，这些方法可能会影响疾病进程。
对一组最初接受局部润滑剂治疗的患者的治疗结果进行研究。纳入117例连续1年以上有复发性糜烂病史的患者，记录其基线特征，并开始使用润滑剂治疗。4年后对患者进行调查，询问其症状及所需治疗。
最初队列中的94例（80%）患者被随访。平均年龄为44岁，性别分布为男性44例，女性50例。平均随访时间为48个月。55例（59%）仍有症状，发作中位频率为60天。13例患者（24%）至少每周发作一次，28例患者（51%）至少每月发作一次。中位疼痛评分（1 - 10分的视觉模拟评分）为2.5分。上皮基底膜营养不良（EBMD）患者中有75%（n = 21）有症状，而创伤性病因患者中有46%（n = 28）有症状。这种差异具有统计学意义（p = 0.02）。与创伤组相比，EBMD患者更有可能继续使用局部润滑剂。
创伤性病因患者比EBMD患者患慢性复发性糜烂综合征的可能性更小。
