Uchio E, Miyakawa K, Ikezawa Z, Ohno S
Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
Br J Ophthalmol. 1998 Jan;82(1):82-7. doi: 10.1136/bjo.82.1.82.
Clinical factors and data from recent cases of atopic dermatitis (AD) (with or without ocular complications) and non-AD cases were examined to evaluate the mechanism of atopic ocular complications.
IgE-RAST for eight allergens including rice, egg, and mite and serum total IgE were measured in 216 patients with AD (70 ocular type, 146 non-ocular type) and 69 non-AD individuals. Tear histamine and leukotriene B4 (LTB4) levels were also measured.
The serum levels of IgE were significantly increased in AD patients with ocular complications compared with those without ocular complications. The positive rates of IgE-RAST for rice and wheat were significantly higher in ocular type AD than in non-ocular type AD. In ocular type AD, serum IgE was significantly increased in patients with cataract compared with that in those without cataract. Tear histamine and LTB4 levels in AD patients with ocular complications showed significant elevations compared with those in patients with pure AD and controls.
These results suggest that ocular type AD belongs to the most severe end of the spectrum of AD, and that some food antigens may contribute to the pathogenesis of severe AD resulting in ocular complications.
研究临床因素以及近期特应性皮炎（AD）病例（伴或不伴眼部并发症）和非AD病例的数据，以评估特应性眼部并发症的机制。
检测了216例AD患者（70例眼部型，146例非眼部型）和69例非AD个体的针对包括大米、鸡蛋和螨虫在内的8种变应原的IgE-RAST及血清总IgE。还检测了泪液组胺和白三烯B4（LTB4）水平。
与无眼部并发症的AD患者相比，有眼部并发症的AD患者血清IgE水平显著升高。眼部型AD患者中大米和小麦的IgE-RAST阳性率显著高于非眼部型AD。在眼部型AD中，与无白内障的患者相比，有白内障的患者血清IgE显著升高。与单纯AD患者和对照组相比，有眼部并发症的AD患者泪液组胺和LTB4水平显著升高。
这些结果表明，眼部型AD属于AD谱系中最严重的一端，一些食物抗原可能参与了导致眼部并发症的重度AD的发病机制。
