Reticular suppression of flash-evoked IPSPs in visual cortex neurons.

In a majority of visual cortex (VC) neurons recorded intracellularly in chronically implanted rabbits, light flashes evoked responses consisting of protracted IPSPs (duration 160-200 msec) followed in some cases by a rebound. Inhibition of spontaneous activity through high frequency reticular stimulation (MRF) or through presentations of non-visual arousing stimuli, was not associated with strong hyperpolarization of the cell membrane. Reticular stimulation evoking both activation and inhibition of spontaneous neuronal activity elicited attenuation or complete elimination elimination (disinhibition) of flash-evoked protracted IPSPs and of the postinhibitory rebounds. Rhythmic neuronal discharges elicited by stimulation of the visual pathway was also reduced during reticular activation, due to attenuation of the IPSP-rebound sequence.