Nagasaki H, Shinagawa K, Mochizuki M
Department of Ophthalmology, Kurume University School of Medicine, Japan.
Prog Retin Eye Res. 1998 Jan;17(1):77-98. doi: 10.1016/s1350-9462(97)00007-4.
Proliferative vitreoretinopathy (PVR) is one of the major causes of failure in retinal detachment surgery. To prevent PVR, it is necessary to determine factors predisposing its development. In primary PVR, large retinal tears, long duration of retinal detachment, vitreous hemorrhages, aphakia and choroidal detachment were demonstrated as clinical risk factors for PVR. In postoperative PVR, it was revealed that large breaks, pre- and postoperative choroidal detachment, minor intra- or postoperative hemorrhages, signs of uveitis, extensive retinal detachment, vitrectomy, cryopexy, air injection and preoperative PVR were risk factors for PVR by multivariate analysis. Almost all risk factors for PVR are associated with intravitreal dispersion of retinal pigment epithelial (RPE) cells or breakdown of the blood-ocular barrier which are prerequisite to development of PVR.
增殖性玻璃体视网膜病变（PVR）是视网膜脱离手术失败的主要原因之一。为预防PVR，有必要确定易引发其发展的因素。在原发性PVR中，大的视网膜裂孔、视网膜脱离的长时间持续、玻璃体积血、无晶状体眼和脉络膜脱离被证明是PVR的临床危险因素。在术后PVR中，多因素分析显示大裂孔、术前和术后脉络膜脱离、术中或术后少量出血、葡萄膜炎体征、广泛视网膜脱离、玻璃体切除术、冷冻疗法、空气注入和术前PVR是PVR的危险因素。几乎所有PVR的危险因素都与视网膜色素上皮（RPE）细胞的玻璃体内扩散或血眼屏障的破坏有关，而这两者是PVR发生发展的先决条件。
