Nossoll M, Teuchert-Noodt G, Dawirs R R
Department of Neuroanatomy, Faculty of Biology, University of Bielefeld, Germany.
Eur J Pharmacol. 1997 Dec 11;340(2-3):R3-5.
A single non-invasive dose of methamphetamine (50 mg/kg i.p.) was administered to neonatal male gerbils (Meriones unguiculatus) aged 14 days. At the age of postnatal day 90, the gamma-aminobutyric acid (GABA) immunoreactive profiles were electron microscopically quantified in the prelimbic area of the prefrontal cortex and compared with those of saline-treated controls. This early solitary drug challenge resulted in adult GABAergic innervation densities which were approximately 40% above those of saline-treated controls.
对14日龄的新生雄性沙鼠（长爪沙鼠）腹腔注射单次非侵入性剂量的甲基苯丙胺（50毫克/千克）。在出生后第90天，通过电子显微镜对前额叶皮质前边缘区中γ-氨基丁酸（GABA）免疫反应性特征进行定量，并与生理盐水处理的对照组进行比较。这种早期的单次药物刺激导致成年期GABA能神经支配密度比生理盐水处理的对照组高出约40%。
