Murata T, Akagi K, Imamura M, Nasu R, Kimura H, Nagata K, Tanaka Y
Department of Radiology, Kansai Medical University, 10-15 Fumizonochou, Moriguchi City, Osaka, 570, Japan.
Oncol Rep. 1998 May-Jun;5(3):705-8. doi: 10.3892/or.5.3.705.
The efficacy of temporary arterial embolization using degradable starch microspheres combined with hyperthermia was investigated in rabbits bearing VX2 tumors. Microsphere injection caused a marked decrease of tumor blood flow and pH. During heating, there was a marked increase of the maximum temperature in tumor tissue compared with normal muscle. Tumor growth was suppressed 330% times at 3 weeks after hyperthermia alone and 270% times following combined treatment with microspheres and hyperthermia. Damage to normal muscle tissue was mild. In conclusion, this combination therapy may be useful for causing selective tumor damage and reducing the effect on normal tissues.
在携带VX2肿瘤的兔子身上研究了使用可降解淀粉微球联合热疗进行临时动脉栓塞的疗效。微球注射导致肿瘤血流和pH值显著降低。加热过程中，与正常肌肉相比，肿瘤组织中的最高温度显著升高。单独热疗3周后肿瘤生长被抑制330倍，微球与热疗联合治疗后肿瘤生长被抑制270倍。对正常肌肉组织的损伤较轻。总之，这种联合治疗可能有助于造成选择性肿瘤损伤并减少对正常组织的影响。
