Murata T, Akagi K, Imamura M, Nasu R, Kimura H, Nagata K, Tanaka Y
Department of Radiology, Kansai Medical University, 10-15 Fumizonochou, Moriguchi City, Osaka, 570, Japan.
Oncol Rep. 1998 May-Jun;5(3):699-703. doi: 10.3892/or.5.3.699.
Arterial ligation was combined with hyperthermia in rabbits with VX2 tumors implanted in the leg. For seven days after arterial ligation, blood flow was decreased and the pH was low in both normal muscle and tumor tissue. The temperature of normal muscle and tumor tissue increased faster and reached a higher level on heating immediately after ligation than without ligation. The antitumor effect of hyperthermia was stronger immediately after ligation than two or seven days afterwards. However, damage to normal muscle was severe with this combination therapy, so a better method of therapeutic arterial blockade is needed.
在腿部植入VX2肿瘤的兔子中，将动脉结扎与热疗相结合。动脉结扎后七天内，正常肌肉和肿瘤组织的血流均减少，pH值降低。与未结扎相比，结扎后立即加热时，正常肌肉和肿瘤组织的温度升高更快，且达到更高水平。热疗的抗肿瘤作用在结扎后立即比两天或七天后更强。然而，这种联合治疗对正常肌肉的损伤严重，因此需要一种更好的治疗性动脉阻断方法。
