Root-Bernstein R S, Holsworth D D
Department of Physiology, Michigan State University, Lansing 48824, USA.
J Theor Biol. 1998 Jan 21;190(2):107-19. doi: 10.1006/jtbi.1997.0544.
Antisense peptides are defined as those generated from the non-coding strand of DNA, and represent a peptide analog to antisense RNA technologies. Peptides generated from both parallel and anti-parallel readings of the non-coding strand of DNA have displayed biological activity, although considerable controversy exists concerning the mechanism(s) by which these "anti-peptides" exert their effects. This paper provides a critical review of some of the key data and issues defining this emerging field and focuses on contradictions and discrepancies in the current studies. We also suggest some directions for future research such as more physico-chemical studies and the use of combinatorial chemistry techniques combined with solid phase binding studies to test, once and for all, the generality and specificity of antisense peptide interactions.
反义肽被定义为由DNA非编码链产生的肽，是反义RNA技术的肽类似物。从DNA非编码链的平行和反平行阅读中产生的肽都显示出生物活性，尽管关于这些“反肽”发挥作用的机制存在相当大的争议。本文对定义这一新兴领域的一些关键数据和问题进行了批判性综述，并关注当前研究中的矛盾和差异。我们还提出了一些未来研究的方向，如更多的物理化学研究，以及结合固相结合研究使用组合化学技术，以一劳永逸地测试反义肽相互作用的普遍性和特异性。
