The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Front Med. 2011 Mar;5(1):8-14. doi: 10.1007/s11684-011-0109-y. Epub 2011 Mar 17.
Brain-dead donors have become one of the main sources of organs for transplantation in Western countries. The quality of donor organs is closely related to the outcome of the transplantation. Experimental studies have confirmed the inferior graft survival of livers from brain-dead donors compared with those from living donors. Studies conducted in the past 10 years have shown that brain death is associated with effects on the decreased donor organ quality. However, whether the decrease in the viability of donor organs is caused by brain death or by the events before and after brain death remains uncertain. The purpose of this review is to introduce the advances and controversies regarding the influence of brain death on the viability of donor livers and to summarize the mechanisms of the different protective interventions for donor livers.
脑死亡供体已成为西方国家器官移植的主要来源之一。供体器官的质量与移植的结果密切相关。实验研究已经证实，与来自活体供体的肝脏相比，脑死亡供体的肝脏移植物存活率较低。过去 10 年的研究表明，脑死亡与供体器官质量下降有关。然而，供体器官活力的下降是由脑死亡引起的，还是由脑死亡前后的事件引起的，目前仍不确定。本文旨在介绍脑死亡对供肝活力的影响的研究进展和争议，并总结不同供肝保护干预措施的机制。
