Aterman K, Krause V W, Ross J B
Can Med Assoc J. 1976 Sep 4;115(5):443-4.
Letterer-Siwe's disease was diagnosed from clinical appearance and initial assessment of a skin biopsy in a child with a 2-month history of skin rash. Fine erythematous papules were scattered on the trunk. The biopsy showed epidermal thickening and an inflammatory infiltrate chiefly in the upper layers of the dermis; deeper in the dermis the infiltrate was perivascular and periappendicular, histiocytes predominating in some areas and lymphocytes in others. A diagnosis of scabies was made after burrows were demonstrated on palms and soles and the mite of scabies was isolated from them.
根据一名有2个月皮疹病史儿童的临床表现及皮肤活检的初步评估，诊断为勒-雪病。躯干散在分布着细小的红斑丘疹。活检显示表皮增厚，炎症浸润主要位于真皮上层；真皮深层的浸润呈血管周围和毛囊周围分布，某些区域以组织细胞为主，其他区域以淋巴细胞为主。在手掌和脚底发现疥虫隧道并从中分离出疥螨后，诊断为疥疮。
