Bannoura M D, Kraebel K S, Spear L P, Spear N E
Center for Developmental Psychobiology, Binghamton University, NY 13902-6000, USA.
Alcohol. 1998 Apr;15(3):213-7. doi: 10.1016/s0741-8329(97)00122-5.
Preweaning exposure to a foreign odor has been shown to alter later responding to that odor. Early experience with ethanol odor may alter not only responding to ethanol odor, but also intake of ethanol solutions. The present study tested the effects of exposure to ethanol odor prior to weaning on ethanol odor preference and ethanol consumption. Sprague-Dawley-derived rats were exposed to the odor of 100% ethanol from postnatal day 1 to 22 in the home cage. An odor preference test was conducted on postnatal day 14 and a two-bottle ethanol intake test was conducted after weaning. In both odor preference and intake tests, animals previously exposed to ethanol odor exhibited a greater preference for ethanol than controls. The results demonstrate that early experience with the odor of ethanol can increase ingestion of ethanol later in life.
断奶前接触外来气味已被证明会改变之后对该气味的反应。早期接触乙醇气味不仅可能改变对乙醇气味的反应，还可能改变乙醇溶液的摄入量。本研究测试了断奶前接触乙醇气味对乙醇气味偏好和乙醇消耗量的影响。从斯普拉格-道利大鼠品系衍生而来的大鼠在出生后第1天至第22天在饲养笼中接触100%乙醇的气味。在出生后第14天进行气味偏好测试，并在断奶后进行双瓶乙醇摄入量测试。在气味偏好和摄入量测试中，先前接触乙醇气味的动物比对照组表现出对乙醇更强的偏好。结果表明，早期接触乙醇气味的经历会增加其成年后的乙醇摄入量。
