Petersen J A, Djurhuus C, Koff J, Vinter-Jensen L, Gregersen H
Centre of Biomechanics and Motility, Institute of Experimental Clinical Research, University of Aarhus, Arhuus N, Denmark.
Dig Dis Sci. 1998 Mar;43(3):521-8. doi: 10.1023/a:1018802922374.
The dose- and time-dependent effects of endoscopic sclerotherapy on luminal cross-sectional area and wall distensibility were studied in pigs at 5 and 12 cm proximal to the gastroesophageal junction by means of impedance planimetry. Sixteen healthy animals underwent two sessions of endoscopic sclerotherapy two weeks apart with injections of either 5 or 10 ml of 1% Polidocanol in the distal 7 cm of the esophagus each time. The animals were investigated before sclerotherapy, two weeks after each session, and finally six weeks after the last session. Six healthy animals were studied as controls. Endoscopic sclerotherapy caused luminal narrowing in the sclerosed zone followed by normalization six weeks after the last treatment (P < 0.05 in both groups). Wall distensibility decreased in the sclerosed zone after treatment with 10 ml sclerosant (P < 0.05) followed by partial normalization, while no effect was found after 5 ml sclerosant (P > 0.2). Progressive dilations were observed in the proximal esophagus in both groups and were most pronounced in the 10 ml group (P < 0.05). Wall distensibility did not change proximal to the site of sclerotherapy in either group (P > 0.1).
通过阻抗平面测量法，研究了内镜硬化治疗对猪食管胃交界近端5厘米和12厘米处管腔横截面积和管壁扩张性的剂量和时间依赖性影响。16只健康动物每隔两周接受两次内镜硬化治疗，每次在食管远端7厘米处注射5或10毫升1%的聚多卡醇。在硬化治疗前、每次治疗后两周以及最后一次治疗后六周对动物进行研究。6只健康动物作为对照。内镜硬化治疗导致硬化区域管腔狭窄，在最后一次治疗后六周恢复正常（两组P均<0.05）。用10毫升硬化剂治疗后，硬化区域的管壁扩张性降低（P<0.05），随后部分恢复正常，而用5毫升硬化剂治疗后未发现影响（P>0.2）。两组食管近端均观察到进行性扩张，在10毫升组中最为明显（P<0.05）。两组硬化治疗部位近端的管壁扩张性均未改变（P>0.1）。
