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具有降压特性的天然存在的2'-O-甲基嘌呤核苷。

Naturally occurring 2'-O-methylpurine nucleosides with hypotensive properties.

作者信息

Yamada T, Kageyama K, Joh Y, Konishi J, Ienaga K

机构信息

Institute of Bio-Active Science, Nippon Zoki Pharm. Co. Ltd., Hyogo, Japan.

出版信息

Cell Mol Life Sci. 1998 Feb;54(2):125-8. doi: 10.1007/s000180050131.

DOI:10.1007/s000180050131
PMID:9539952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11147228/
Abstract

2'-O-Methylinosine (1) has been isolated for the first time and shown to be an intrinsic hypotensive principle. Its probable in vivo precursor, 2'-O-methyladenosine (3), showed stronger and even orally potent hypotensive activity. Resistance of the methyladenosine (3) against adenosine deaminase is thought to contribute to its long-lasting activity. The effect of both nucleosides (1 and 3) was not accompanied with any significant change in heart rate, which is often observed with adenosine.

摘要

2'-O-甲基肌苷（1）首次被分离出来，并被证明是一种内源性降压物质。其可能的体内前体2'-O-甲基腺苷（3）表现出更强甚至口服有效的降压活性。甲基腺苷（3）对腺苷脱氨酶的抗性被认为有助于其持久的活性。两种核苷（1和3）的作用都没有伴随着心率的任何显著变化，而腺苷通常会引起这种变化。

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