新型杂[2,1]苯并噻氮䓬衍生物的抗抑郁活性
Antidepressant activity of new hetero[2,1]benzothiazepine derivatives.
作者信息
Vega S, Diaz J A, Darias V, Sanchez Mateo C C, Albertos L M
机构信息
Instituto de Química Médica, CSIC, Madrid.
出版信息
Pharmazie. 1998 Feb;53(2):130-4.
PMID:9540110
Abstract
A number of thieno and pyrazolo[2,1]benzothiazepine derivatives as well as several synthetic intermediate compounds were tested for acute toxicity and antidepressant activity in mice. Some of these compounds were effective in the tetrabenazine and Porsolt tests.
摘要
对多种噻吩并和吡唑并[2,1]苯并硫氮杂䓬衍生物以及几种合成中间体化合物进行了小鼠急性毒性和抗抑郁活性测试。其中一些化合物在利血平和波索尔特试验中有效。
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