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冠状动脉闭塞后缺血和非缺血犬心肌中高能磷酸盐、核苷酸衍生物及收缩力的急性变化

Acute changes in high energy phosphates, nucleotide derivatives, and contractile force in ischaemic and nonischaemic canine myocardium following coronary occlusion.

作者信息

Jones C E, Thomas J X, Parker J C, Parker R E

出版信息

Cardiovasc Res. 1976 May;10(3):275-82. doi: 10.1093/cvr/10.3.275.

DOI:10.1093/cvr/10.3.275
PMID:954015
Abstract

Studies of ischaemic myocardium following occlusion of coronary arterial branches revealed a substantial decline in creatine phosphate, adenosine triphosphate, and total adenine nucleotide contents over 40 min. Contents of nucleotide breakdown derivatives increased significantly but transiently. Contractile force declined rapidly and stabilized at a low level. In nonischaemic muscle following occlusion creatine phosphate, adenosine triphosphate, and total nucleotide contents declined rapidly, although not to the degree seen in ischaemic muscle. Contents of derivatives increased only slightly. Contractile force increased.

摘要

冠状动脉分支闭塞后对缺血心肌的研究显示,在40分钟内磷酸肌酸、三磷酸腺苷和总腺嘌呤核苷酸含量大幅下降。核苷酸分解衍生物的含量显著但短暂增加。收缩力迅速下降并稳定在低水平。在闭塞后的非缺血肌肉中,磷酸肌酸、三磷酸腺苷和总核苷酸含量迅速下降,尽管下降程度不如缺血肌肉中所见。衍生物的含量仅略有增加。收缩力增加。

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1
Acute changes in high energy phosphates, nucleotide derivatives, and contractile force in ischaemic and nonischaemic canine myocardium following coronary occlusion.冠状动脉闭塞后缺血和非缺血犬心肌中高能磷酸盐、核苷酸衍生物及收缩力的急性变化
Cardiovasc Res. 1976 May;10(3):275-82. doi: 10.1093/cvr/10.3.275.
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Regional myocardial energetics during brief periods of coronary occlusion and reperfusion: Comparison with S-T segment changes.冠状动脉闭塞和再灌注短时间内的局部心肌能量代谢:与ST段改变的比较。
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3
Lethal myocardial ischemic injury.致死性心肌缺血损伤
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Correlation of contractile dysfunction with oxidative energy production and tissue high energy phosphate stores during partial coronary flow disruption in rabbit heart.兔心脏局部冠状动脉血流中断期间收缩功能障碍与氧化能量产生及组织高能磷酸储存的相关性
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Relation between high energy phosphate and lethal injury in myocardial ischemia in the dog.犬心肌缺血时高能磷酸与致死性损伤的关系
Am J Pathol. 1978 Jul;92(1):187-214.