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训练对遭受缺血缺氧条件的大鼠心肌反应的影响。

Influence of training on myocardial responses of rats subjected to conditions of ischaemia and hypoxia.

作者信息

Carey R A, Tipton C M, Lund D R

出版信息

Cardiovasc Res. 1976 May;10(3):359-67. doi: 10.1093/cvr/10.3.359.

DOI:10.1093/cvr/10.3.359
PMID:954020
Abstract

Physical training has been advocated to minimize the problems associated with coronary heart disease; however, the responsible mechanisms are obscure. Rats trained to run on a treadmill were subjected to acute conditions of hypoxia and myocardial ischaemia. Trained rats were better able to maintain a higher level of cardiac performance (dP/dt max) after hypoxia than non-trained rats, but no advantages were apparent after ischaemia. Biochemical data showed no myocardial differences between the groups in oxygen utilization or energy availability.

摘要

体育锻炼已被提倡用于尽量减少与冠心病相关的问题;然而,其相关机制尚不清楚。训练在跑步机上跑步的大鼠经受急性缺氧和心肌缺血状况。与未训练的大鼠相比,训练后的大鼠在缺氧后能更好地维持较高水平的心脏功能(最大dp/dt),但在缺血后未表现出优势。生化数据显示两组在氧利用或能量供应方面心肌无差异。

相似文献

1
Influence of training on myocardial responses of rats subjected to conditions of ischaemia and hypoxia.训练对遭受缺血缺氧条件的大鼠心肌反应的影响。
Cardiovasc Res. 1976 May;10(3):359-67. doi: 10.1093/cvr/10.3.359.
2
Effect of physical training on the mechanical and metabolic response of the rat heart to hypoxia.体育锻炼对大鼠心脏低氧机械和代谢反应的影响。
Circ Res. 1972 Apr;30(4):418-29. doi: 10.1161/01.res.30.4.418.
3
Myocardial substrate levels in vivo during hypoxia of various degrees and duration.不同程度和持续时间的缺氧状态下体内心肌底物水平。
Recent Adv Stud Cardiac Struct Metab. 1975;7:275-82.
4
Metabolism of the acutely ischemic and hypoxic heart.急性缺血缺氧心脏的代谢
Crit Care Med. 1973 Nov-Dec;1(6):321-30. doi: 10.1097/00003246-197311000-00006.
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Acute alterations in energetics of ischemic heart muscle.
Cardiology. 1971;56(1):232-44. doi: 10.1159/000169368.
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Symposium on Myocardial Blood Flow in Man--Methods and Significance in Myocardial Disease: Pisa, Italy; June 10-12, 1971. Report of the session on acute hypoxia.人类心肌血流研讨会——心肌疾病的方法与意义:意大利比萨;1971年6月10日至12日。急性缺氧会议报告
Cardiology. 1972;57(1):73-88.
7
[Molecular mechanisms of cardiac insufficiency in myocardial ischemia].[心肌缺血性心力衰竭的分子机制]
Kardiologiia. 1976 Apr;16(4):5-13.
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High energy phosphate compounds and mitochondrial function in ischemic myocardium of swine with advanced coronary atherosclerosis.晚期冠状动脉粥样硬化猪缺血心肌中的高能磷酸化合物与线粒体功能
J Mol Cell Cardiol. 1973 Dec;5(6):515-26. doi: 10.1016/0022-2828(73)90003-5.
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[Effectiveness of the utilization of energy in the hypertrophied heart].[肥厚型心脏中能量利用的有效性]
Kardiologiia. 1971 Jun;11(6):10-8.
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Pathogenic significance of disproportion between myocardial oxygen supply and consumption.心肌氧供与氧耗失衡的致病意义。
Recent Adv Stud Cardiac Struct Metab. 1972;1:721-8.

引用本文的文献

1
Effects of physical training on myocardial ischaemia in patients with coronary artery disease.体育锻炼对冠状动脉疾病患者心肌缺血的影响。
Br Heart J. 1980 Mar;43(3):262-9. doi: 10.1136/hrt.43.3.262.
2
Chronic exercise training protects aged cardiac muscle against hypoxia.长期运动训练可保护老年心肌免受缺氧影响。
J Clin Invest. 1989 Mar;83(3):778-84. doi: 10.1172/JCI113957.
3
Effect of prolonged intensive training on cardiorespiratory response in patients with angina pectoris.长期强化训练对心绞痛患者心肺反应的影响。
Br Heart J. 1978 Oct;40(10):1143-8. doi: 10.1136/hrt.40.10.1143.