Matsumoto M, Reichel E, Puliafito C A, Duker J S
New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
Osaka City Med J. 1997 Dec;43(2):139-51.
The purpose of this study was to determine the nature of the relationship between density of indocyanine green (ICG) and the activity of occult choroidal neovascular membranes (CNVM) in patients with age-related macular degeneration (AMD) using ICG angiography. Ten eyes of ten patients with AMD and associated CNVM formation were retrospectively classified into either active or silent group on the basis of clinical outcome. Density of ICG for ICG leakage of CNVM was retrospectively determined from baseline ICG angiograms using an image analysis system. The means of relative density of the two groups were significantly different at five minutes after injection of ICG (p = 0.02). Densitometric analysis with ICG angiography may enable the discrimination of active from silent CNVM in patients with AMD, and thereby, prove useful in guiding clinical decision concerning treatment of these patients.
本研究的目的是利用吲哚菁绿（ICG）血管造影术确定年龄相关性黄斑变性（AMD）患者中吲哚菁绿（ICG）密度与隐匿性脉络膜新生血管膜（CNVM）活性之间的关系性质。对10例患有AMD并伴有CNVM形成的患者的10只眼，根据临床结果进行回顾性分类，分为活动组或静止组。使用图像分析系统从基线ICG血管造影片中回顾性确定CNVM的ICG渗漏的ICG密度。在注射ICG后五分钟，两组的相对密度平均值有显著差异（p = 0.02）。ICG血管造影的密度分析可能有助于鉴别AMD患者中活动期与静止期的CNVM，从而在指导这些患者的治疗临床决策方面证明是有用的。
