Thomas B L, Tucker A S, Ferguson C, Qiu M, Rubenstein J L, Sharpe P T
Department of Craniofacial Development, Guy's Hospital, London, UK.
Eur J Oral Sci. 1998 Jan;106 Suppl 1:44-7. doi: 10.1111/j.1600-0722.1998.tb02152.x.
We have previously proposed that the patterning of the mammalian dentition is determined by an odontogenic homeobox code, whereby positional specification of odontogenic ectomesenchymal cell populations in a given region of the first branchial arch are determined by the combination of different homeobox genes expressed, described in detail in (1). Here we describe the first functional evidence for such a mechanism, and show that development of different types of teeth is controlled by independent genetic pathways. We suggest a mechanism whereby patterning is determined by position dependent control of tooth germ initiation, and propose that the pathway of morphogenesis is directly linked to the early mesenchymal expression of homeobox genes.
我们之前曾提出，哺乳动物牙列的模式是由一个牙源性同源框密码决定的，据此，第一鳃弓特定区域内牙源性外胚间充质细胞群的位置特化由所表达的不同同源框基因的组合决定，详见文献(1)。在此，我们描述了这一机制的首个功能证据，并表明不同类型牙齿的发育由独立的遗传途径控制。我们提出一种机制，即模式是由牙胚起始的位置依赖性控制决定的，并认为形态发生途径与同源框基因的早期间充质表达直接相关。
