以可逆性后部白质脑病综合征形式出现的顺铂神经毒性。
Cisplatin neurotoxicity presenting as reversible posterior leukoencephalopathy syndrome.
作者信息
Ito Y, Arahata Y, Goto Y, Hirayama M, Nagamutsu M, Yasuda T, Yanagi T, Sobue G
机构信息
Department of Neurology, Nagoya University School of Medicine, Japan.
出版信息
AJNR Am J Neuroradiol. 1998 Mar;19(3):415-7.
Abstract
Visual disturbance, hypertension, convulsions, and unconsciousness developed in a 70-year-old man after cisplatin chemotherapy and upper-limb amputation for osteosarcoma. MR imaging revealed bilateral reversible abnormalities in the occipital, parietal, and frontal white matter. Clinical and neuroradiologic features corresponded to reversible posterior leukoencephalopathy syndrome (RPLS), which some immunosuppressive and chemotherapeutic drugs have been reported to trigger. Cisplatin may be among these drugs. Our patient also had hypomagnesemia, which may have figured in the pathophysiology.
摘要
一名70岁男性在接受顺铂化疗及因骨肉瘤进行上肢截肢术后，出现了视觉障碍、高血压、惊厥和意识丧失。磁共振成像显示枕叶、顶叶和额叶白质出现双侧可逆性异常。临床和神经放射学特征符合可逆性后部白质脑病综合征（RPLS），据报道一些免疫抑制和化疗药物可引发该综合征。顺铂可能是其中之一。我们的患者还存在低镁血症，这可能在病理生理过程中起了作用。
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