Laskawi R, Rödel R, Zirk A, Arglebe C
ENT Department, University of Göttingen, Germany.
J Oral Maxillofac Surg. 1998 Apr;56(4):440-3. doi: 10.1016/s0278-2391(98)90708-x.
This retrospective study evaluated data pertaining to the history, symptoms, treatment, and prognosis of a series of patients treated for acinic cell carcinoma (ACC).
Data were based on the records of 35 patients. Follow-up was done by analyzing their records and contacting the referring doctors.
In 71% of the ACC patients, painful swelling of the lateral region of the face was the main symptom. Facial paralysis occurred in 11% of cases before treatment. Tumor recurrence after therapy was noted in 42% of cases. Highly differentiated ACC was the most frequent histologic subtype (74%). The grade of differentiation of the tumor was decisive for the prognosis. Highly differentiated ACC had a better prognosis (2 years overall survival, 100%; 5 years overall survival, 83%; 10 years overall survival, 50%) than lowly differentiated tumors (2 years overall survival, 70%; 5 years overall survival, 50%; 10 years overall survival, 30%).
ACC is a rare tumor located mainly in the parotid gland that is characterized by some special attributes. Surgery is the therapy of choice. Prognosis depends mainly on the histologic subtype.
本回顾性研究评估了一系列接受腺泡细胞癌（ACC）治疗的患者的病史、症状、治疗及预后相关数据。
数据基于35例患者的记录。通过分析他们的记录并联系转诊医生进行随访。
在71%的ACC患者中，面部外侧区域的疼痛性肿胀是主要症状。11%的病例在治疗前出现面瘫。42%的病例在治疗后出现肿瘤复发。高分化ACC是最常见的组织学亚型（74%）。肿瘤的分化程度对预后起决定性作用。高分化ACC的预后（2年总生存率100%；5年总生存率83%；10年总生存率50%）优于低分化肿瘤（2年总生存率70%；5年总生存率50%；10年总生存率30%）。
ACC是一种主要位于腮腺的罕见肿瘤，具有一些特殊特征。手术是首选治疗方法。预后主要取决于组织学亚型。
