同源甲基化核糖核酸对病毒增殖的抑制作用。V. 对小鼠体内黏液病毒的抑制作用
Inhibition of viral multiplication by homologous methylated ribonucleic acids. V. Inhibition of myxoviruses in mouse.
作者信息
Louisot P, Levrat C, Befort N, Beck G, Ebel J P
出版信息
Chem Biol Interact. 1976 Aug;14(3-4):233-40. doi: 10.1016/0009-2797(76)90103-4.
PMID:954144
Abstract
Mice respond to intravenous injection of homologous methylated RNA by the production of a circulating interferon-like substance. The treatment with modified RNA induces a significant protection against viral infection. This effect is optimum when the treatment occurs a few hours before viral infection. The protective effect is a peculiar property of homologous methylated RNA as heterologous RNAs do not induce any resistance to the infection with influenza virus.
摘要
小鼠通过产生一种循环的干扰素样物质来响应静脉注射同源甲基化RNA。用修饰的RNA进行治疗可诱导对病毒感染的显著保护作用。当在病毒感染前几小时进行治疗时，这种效果最佳。这种保护作用是同源甲基化RNA的一种特殊特性，因为异源RNA不会诱导对流感病毒感染的任何抗性。
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