赤子爱胜蚓中细胞溶解因子的细胞表达。

Cellular expression of the cytolytic factor in earthworms Eisenia foetida.

作者信息

Bilej M, Rossmann P, Sinkora M, Hanusová R, Beschin A, Raes G, De Baetselier P

机构信息

Department of Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídenská, Prague.

出版信息

Immunol Lett. 1998 Jan;60(1):23-9. doi: 10.1016/s0165-2478(97)00127-2.

DOI:10.1016/s0165-2478(97)00127-2

PMID:9541459

Abstract

Coelomic fluid of earthworms contains a 42 kDa protein designated CCF-1 (coelomic cytolytic factor 1), which accounts for approximately 40% of cytolytic activity of the entire coelomic fluid. CCF-1 was documented to be present on cells of the mesenchymal lining of the coelomic cavity as well as on free coelomocytes. Both cellular and humoral levels of CCF-1 were significantly increased after parenteral injection of endotoxin. Moreover, CCF-1 seems to be involved in cell mediated cytotoxicity, because cytotoxic activity is blocked in the presence of anti-CCF-1 monoclonal antibody (mAb).

摘要

蚯蚓的体腔液含有一种名为CCF-1（体腔溶细胞因子1）的42 kDa蛋白质，它约占整个体腔液溶细胞活性的40%。据记载，CCF-1存在于体腔间质内衬细胞以及游离的体腔细胞上。经肠道外注射内毒素后，CCF-1的细胞水平和体液水平均显著升高。此外，CCF-1似乎参与细胞介导的细胞毒性作用，因为在存在抗CCF-1单克隆抗体（mAb）的情况下，细胞毒性活性受到抑制。