Magos L, Clarkson T W
Chem Biol Interact. 1976 Aug;14(3-4):325-35. doi: 10.1016/0009-2797(76)90111-3.
Mice dosed with methylmercury chloride (0.5 to 2.0 mg Hg/kg i.p.) labeled with the 203Hg isotope were given polythiol resin in their food (2% w/w). The effect of pretreatment with phenobarbitone, or co-administration of D-penicillamine or L-cysteine, was tested on the efficacy of the resin to accelerate the excretion of methylmercury. The effect of the polythiol resin in enhancing fecal excretion was dependent on the dose of methylmercury, it being significantly greater at doses of 1.0 and 2.0 than at 0.5 mg Hg/kg. In animals given the resin and phenobarbitone (0.1% w/w drinking water), fecal excretion was approx. 36% greater than in animals given resin alone. Penicillamine (2.5 mg/ml drinking water) actually retarted elimination of methylmercury in animals given the resin. Despite the enhanced efficacy of the resin plus phenobarbitone, the brain levels of methylmercury were not reduced beyond those seen in animals given resin alone. The mechanisms and implications of these effects are discussed.
给经腹腔注射203Hg同位素标记的氯化甲基汞（0.5至2.0毫克汞/千克）的小鼠喂食含多硫醇树脂（2%重量/重量）的食物。测试了用苯巴比妥预处理，或同时给予D-青霉胺或L-半胱氨酸对树脂促进甲基汞排泄功效的影响。多硫醇树脂增强粪便排泄的效果取决于甲基汞的剂量，在1.0和2.0毫克汞/千克剂量时比在0.5毫克汞/千克时显著更强。在给予树脂和苯巴比妥（0.1%重量/重量饮用水）的动物中，粪便排泄量比仅给予树脂的动物大约多36%。青霉胺（2.5毫克/毫升饮用水）实际上延缓了给予树脂的动物体内甲基汞的消除。尽管树脂加苯巴比妥的功效增强了，但甲基汞的脑内水平并未降低到低于仅给予树脂的动物所见水平。讨论了这些作用的机制和意义。
