Vega E, Ghiringhelli G, Mautalen C, Rey Valzacchi G, Scaglia H, Zylberstein C
Sección Osteopatías Médicas, Hospital de Clínicas, Córdoba 2351. Piso 8., 1120 Buenos Aires, Argentina.
Calcif Tissue Int. 1998 May;62(5):465-9. doi: 10.1007/s002239900462.
The bone mineral density (BMD) at the lumbar spine, proximal femur, and total skeleton was evaluated in 38 men with primary osteoporosis and vertebral fractures. BMD of the patients was significantly reduced over all skeletal areas compared with controls. The Z-score of the lumbar spine (-2.8 +/- 0.9) was less than that of the other areas (P < 0.001) except the legs (-2.5 +/- 1.1) (p.n.s.) showing that bone loss had a tendency to be greater over the axial skeleton. Vertebral dimensions compared with age-matched controls were as follows: projected L2-L4 area (cm 2): 45.7 +/- 5.6 versus 53.7 +/- 3. 6 (P < 0.001); vertebral width (cm): 4.37 +/- 0.44 versus 4.90 +/- 0. 36 (P < 0.001). Serum biochemical parameters and testosterone levels were similar between osteoporotic and control men. We conclude that men with vertebral osteoporotic fractures have reduced vertebral BMD and vertebral dimensions compared with age-matched controls. Thus, these findings indicate that the achievement of a reduced bone size at the end of the growth period or a failure of periosteal increase during adult life is likely to contribute to the pathogenesis of the vertebral fractures observed in older men.
对38例患有原发性骨质疏松症和椎体骨折的男性患者的腰椎、股骨近端和全身骨骼的骨密度（BMD）进行了评估。与对照组相比，患者在所有骨骼区域的骨密度均显著降低。腰椎的Z值（-2.8±0.9）低于其他区域（P<0.001），但腿部除外（-2.5±1.1）（无统计学意义），这表明轴向骨骼的骨质流失趋势更大。与年龄匹配的对照组相比，椎体尺寸如下：L2-L4投影面积（cm²）：45.7±5.6 对比 53.7±3.6（P<0.001）；椎体宽度（cm）：4.37±0.44 对比 4.90±0.36（P<0.001）。骨质疏松男性和对照男性的血清生化参数及睾酮水平相似。我们得出结论，与年龄匹配的对照组相比，患有椎体骨质疏松性骨折的男性椎体骨密度和椎体尺寸降低。因此，这些发现表明，成年期生长结束时骨尺寸减小或骨膜生长失败可能是导致老年男性椎体骨折发病机制的原因。
