Pouresmaeili Farkhondeh, Kamalidehghan Behnam, Kamarehei Maryam, Goh Yong Meng
Infertility and Reproductive Health Research Center (IRHRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Medical Genetics Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Ther Clin Risk Manag. 2018 Nov 6;14:2029-2049. doi: 10.2147/TCRM.S138000. eCollection 2018.
Osteoporosis is a bone disorder with remarkable changes in bone biologic material and consequent bone structural distraction, affecting millions of people around the world from different ethnic groups. Bone fragility is the worse outcome of the disease, which needs long term therapy and medical management, especially in the elderly. Many involved genes including environmental factors have been introduced as the disease risk factors so far, of which genes should be considered as effective early diagnosis biomarkers, especially for the individuals from high-risk families. In this review, a number of important criteria involved in osteoporosis are addressed and discussed.
骨质疏松症是一种骨骼疾病，骨生物材料发生显著变化，进而导致骨结构破坏，影响着世界各地数百万不同种族的人群。骨脆性是该疾病最严重的后果，需要长期治疗和医疗管理，尤其是在老年人中。到目前为止，许多涉及的基因包括环境因素都被认为是该疾病的危险因素，其中一些基因应被视为有效的早期诊断生物标志物，特别是对于来自高危家庭的个体。在这篇综述中，探讨并讨论了骨质疏松症涉及的一些重要标准。
