Reitz M, DasGupta K, Löber G, Kleemann P
Clinic of Anesthesiology, University of Mainz, Germany.
Arzneimittelforschung. 1998 Feb;48(2):120-4.
The rate of DNA single strand-breaks in lymphocytes of 160 human donors were determined after enflurane (CAS 13838-16-9) exposure in vitro. The rate of DNA damage increased in relation to the exposed enflurane concentration. However, not every lymphocyte sample showed an increased rate of DNA damage; some samples showed an increased rate even after exposure to only 0.4 vol% enflurane and other samples showed no increased rate even after exposure to 4.0 vol% enflurane. After exposure to 0.6 vol% enflurane and more the increased rate of DNA damage is statistically significant. The DNA damage in the lymphocytes differs individually. The reasons may be genetic differences in DNA repair. In patients with DNA repair deficiencies anesthesia with enflurane may induce irreversible DNA damage.
在体外暴露于恩氟烷（CAS 13838-16-9）后，测定了160名人类供体淋巴细胞中DNA单链断裂的速率。DNA损伤速率随暴露的恩氟烷浓度增加而升高。然而，并非每个淋巴细胞样本的DNA损伤速率都增加；一些样本即使仅暴露于0.4%体积分数的恩氟烷后DNA损伤速率也增加，而其他样本即使暴露于4.0%体积分数的恩氟烷后DNA损伤速率也未增加。暴露于0.6%体积分数及更高浓度的恩氟烷后，DNA损伤速率的增加具有统计学意义。淋巴细胞中的DNA损伤存在个体差异。原因可能是DNA修复的基因差异。在存在DNA修复缺陷的患者中，使用恩氟烷麻醉可能会诱导不可逆的DNA损伤。
