Reitz M, Lanz E
Department of Physiological Chemistry, University of Mainz (Fed. Rep. of Germany.
Arzneimittelforschung. 1993 Apr;43(4):418-20.
Halothane (CAS 151-67-7) induced DNA strand breaks in isolated lymphocytes of two patients with a deficient DNA repair (xeroderma pigmentosum). In lymphocytes (resting cells) of healthy human donors and in L 5178 Y cells (proliferating cells) of mouse lymphoma, halothane did not induce demonstrable DNA strand breaks. The cells were exposed to 1.0 vol/% halothane for 60 min, and the DNA strand breaks were demonstrated by alkaline elution. The results suggest a possible genotoxic side effect of halothane in patients with deficiency in DNA repair.
氟烷（CAS 151-67-7）在两名DNA修复缺陷（着色性干皮病）患者的离体淋巴细胞中诱导了DNA链断裂。在健康人类供体的淋巴细胞（静息细胞）和小鼠淋巴瘤的L 5178 Y细胞（增殖细胞）中，氟烷未诱导出可证实的DNA链断裂。将细胞暴露于1.0体积%的氟烷中60分钟，通过碱性洗脱法证实DNA链断裂。结果表明氟烷对DNA修复缺陷患者可能存在遗传毒性副作用。
