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Synthesis of new thieno [2,3-d]pyrimidine-2,4(1H,3H)-diones with analgesic and anti-inflammatory activities.

作者信息

Romeo G, Russo F, Caruso A, Cutuli V, Amico-Roxas M

机构信息

Istituto di Farmacologia, Facoltá di Medicina, Università di Catania, Italy.

出版信息

Arzneimittelforschung. 1998 Feb;48(2):167-72.

PMID:9541728
Abstract

A series of new 1,3-disubstituted thieno[1,3-d]pyrimidine-2,4(1H,3H)-diones were prepared to investigate their analgesic and anti-inflammatory properties. The analgesic and anti-inflammatory activities of synthesized compounds were investigated by the phenylquinone-induced writhing syndrome test, carrageenan rat paw oedema test and acetic acid-induced peritonitis assay. Most of the new compounds were found to be superior to mefenamic acid, as they were devoid of any ulcerogenic activity.

摘要

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