家猪（Sus scrofa domestica L.）中9例相互易位的新病例。

Nine new cases of reciprocal translocation in the domestic pig (Sus scrofa domestica L.).

作者信息

Ducos A, Berland H M, Pinton A, Guillemot E, Seguela A, Blanc M F, Darre A, Darre R

机构信息

URA INRA-ENVT de Cytogenetique des Populations Animales, Ecole Nationale Veterinaire de Toulouse, France.

出版信息

J Hered. 1998 Mar-Apr;89(2):136-42. doi: 10.1093/jhered/89.2.136.

DOI:10.1093/jhered/89.2.136

PMID:9542161

Abstract

Nine pigs with decreased litter size or sired by boars with decreased litter size were found to be reciprocal translocation carriers. Four Large White animals (two females and two males) demonstrated translocations involving chromosomes 1 and 9 (1p-;9p+), 11 and 13 (11q+;13q-), 3 and 13 (3;13)(p1.5;q3.1), and 15 and 17 (15;17)(q1.3;q2.1). Two Large White x Pietrain terminal boars demonstrated translocations involving chromosomes 11 and 16 (11;16)(p1.4;q1.4), and 6 and 14 (6;14)(q2.7;q2.1). The (9;15)(p2.4;q1.3) and (6;16)(q1.1;q1.1) translocations were found in a Large White x French Landrace boar, and in a commercial male line boar with decreased litter size, respectively. A Gascon breed boar with reduced prolificacy also had an abnormal karyotype, namely 38 XY, rcp(1;6)(q1.2;q2.2). Reduction in prolificacy was estimated accurately in cases 3, 5, 6, 7, and 9 (35%, 30%, 35%, 41%, and 56%, respectively). Rcp(1;6)(q1.2;q2.2) and rcp(6;16)(q1.1;q1.1) seemed to have been of de novo origin.

摘要

研究发现，9头产仔数减少的母猪或由产仔数减少的公猪所生的母猪是相互易位携带者。4头大白猪（2头雌性和2头雄性）表现出涉及染色体1和9（1p-;9p+）、11和13（11q+;13q-）、3和13（3;13）（p1.5;q3.1）以及15和17（15;17）（q1.3;q2.1）的易位。2头大白猪×皮特兰终端公猪表现出涉及染色体11和16（11;16）（p1.4;q1.4）以及6和14（6;14）（q2.7;q2.1）的易位。（9;15）（p2.4;q1.3）和（6;16）（q1.1;q1.1）易位分别在一头大白猪×法国长白公猪以及一头产仔数减少的商业雄性系公猪中被发现。一头繁殖力降低的加斯科涅品种公猪也具有异常核型，即38 XY，rcp(1;6)(q1.2;q2.2)。在病例3、5、6、7和9中，繁殖力降低的估计较为准确（分别为35%、30%、35%、41%和56%）。Rcp(1;6)(q1.2;q2.2)和rcp(6;16)(q1.1;q1.1)似乎是新生的。