Lapolla A, Sanzari M, Marini S, Floriani F, Piva I, Erle G, Fedele D
Cattedra di Malattie del Metabolismo, Università degli Studi, Padua, Italy.
Ann Ist Super Sanita. 1997;33(3):429-32.
We studied the lymphocyte subpopulations in 14 pregnant women with type 1 insulin-dependent diabetes mellitus (IDDM), mean age (+/- SD) 30 +/- 4 years, mean disease duration 12 +/- 5 years, in 14 with gestational diabetes mellitus (GDM) (mean age 33 +/- 6 years) and 21 matched healthy pregnant controls (C), when the subjects delivered, and in their newborn. The GDM and IDDM mothers show a significant increase (p < 0.05) of lymphocytes in comparison with C (GDM 1.83 +/- 0.5 x 10(9)/l, IDDM 1.6 +/- 0.68 x 10(9)/l, C 1.06 +/- 0.45 x 10(9)/l lymphocytes), which has repercussion on lymphocyte subpopulations absolute values. The newborn of GDM mothers have an increase of lymphocytes T-activated (0.6 +/- 0.3 vs 0.3 +/- 0.2%; p < 0.05) and a reduction of NK lymphocytes than C (8.9 +/- 9 vs 15.5 +/- 7.6%; p < 0.05). The newborn of IDDM mothers show a significant reduction of NK lymphocytes than C (10 +/- 6 vs 15.5 +/- 7.6%; p < 0.05). So in newborn of diabetic mothers there is a deficit of natural immunity at birth which has to be evaluated by follow-up study.
我们研究了14例1型胰岛素依赖型糖尿病（IDDM）孕妇、14例妊娠糖尿病（GDM）孕妇（平均年龄33±6岁）以及21例相匹配的健康孕妇对照组（C）分娩时及其新生儿的淋巴细胞亚群情况。14例IDDM孕妇平均年龄（±标准差）为30±4岁，平均病程为12±5年。与对照组相比，GDM和IDDM母亲的淋巴细胞显著增加（p<0.05）（GDM组淋巴细胞为1.83±0.5×10⁹/L，IDDM组为1.6±0.68×10⁹/L，C组为1.06±0.45×10⁹/L），这对淋巴细胞亚群的绝对值产生了影响。GDM母亲的新生儿T激活淋巴细胞增加（0.6±0.3%对0.3±0.2%；p<0.05），NK淋巴细胞比对照组减少（8.9±9对15.5±7.6%；p<0.05）。IDDM母亲的新生儿NK淋巴细胞比对照组显著减少（10±6对15.5±7.6%；p<0.05）。因此，糖尿病母亲的新生儿出生时存在天然免疫缺陷，必须通过随访研究进行评估。
