Buschard K, Kühl C, Mølsted-Pedersen L, Röpke C
Bartholin Institute, Kommunehospitalet, Copenhagen, Denmark.
Diabetes Res. 1990 Aug;14(4):187-90.
The thymus-dependent immune system is involved in the disease process underlying Type 1 diabetes. Several studies have thus shown the distribution of peripheral T-lymphocyte subsets to be altered in diabetics. Unlike many other autoimmune diseases which improve during pregnancy, Type 1 diabetes has a higher incidence in pregnant than in non-pregnant women. Therefore, in this study the distribution of lymphocyte subpopulations in the blood was examined in pregnant, newly diagnosed Type 1 diabetic patients and compared with values from non-pregnant patients and healthy controls. The pregnant diabetics displayed a higher percentage of CD8+ cells (28.4 +/- 1.2%) than the non-pregnant diabetics (21.6 +/- 1.3%, p less than 0.005), but did not differ from the controls (29.0 +/- 1.3%). The CD3+ and CD4+ cell distribution displayed no significant difference within the groups. Among the pregnant diabetics a positive correlation was found between the percentage of CD4+ cells and the week of pregnancy when diabetes was diagnosed (p less than 0.01). No other correlations between immunological and clinical parameters were found. Thus the subsets of immune cells are not changed in an autoimmune direction for pregnant, newly diagnosed Type 1 diabetics as they are for non-pregnant. Therefore, the increased incidence of Type 1 diabetes in pregnant women is unlikely to be due to intensified autoimmune alterations in the immune system, but rather to changes induced in the beta-cells during pregnancy as discussed.
胸腺依赖免疫系统参与了1型糖尿病的发病过程。因此，多项研究表明糖尿病患者外周血T淋巴细胞亚群的分布发生了改变。与许多在孕期病情改善的自身免疫性疾病不同，1型糖尿病在孕妇中的发病率高于非孕妇。因此，在本研究中，对新诊断的妊娠1型糖尿病患者血液中的淋巴细胞亚群分布进行了检测，并与非妊娠患者和健康对照者的值进行了比较。妊娠糖尿病患者的CD8 +细胞百分比（28.4 +/- 1.2％）高于非妊娠糖尿病患者（21.6 +/- 1.3％，p <0.005），但与对照组（29.0 +/- 1.3％）无差异。各组间CD3 +和CD4 +细胞分布无显著差异。在妊娠糖尿病患者中，发现CD4 +细胞百分比与糖尿病诊断时的孕周之间存在正相关（p <0.01）。未发现免疫参数与临床参数之间的其他相关性。因此，对于新诊断的妊娠1型糖尿病患者，其免疫细胞亚群并未像非妊娠患者那样朝着自身免疫方向发生改变。因此，孕妇中1型糖尿病发病率的增加不太可能是由于免疫系统中自身免疫改变加剧，而更可能是如前文所述的孕期β细胞发生的变化所致。
