Olivieri A, Magnani F, Valensise H, D'Archivio M, Medda E, Baccarini S, Sorcini M, Romanini C
Laboratorio di Metabolismo e Biochimica Patologica, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 1997;33(3):447-50.
Presence of antithyroid autoantibodies (ThyAb) during pregnancy is strictly related to the risk of developing post partum thyroiditis (PPT) and this risk is increased in IDDM pregnant women. Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity that begins, or is first diagnosed, during pregnancy. GDM is considered a risk factor for both type 1 and type 2 diabetes and various non-organ specific autoantibodies have been found to be associated with GDM, although there is little information on the association of GDM with thyroid autoimmunity. In this study oral glucose tolerance and prevalence of ThyAb were evaluated in a group of 41 pregnant women at increased risk of developing GDM and in a healthy control group. Our results showed that 22% of GDM risk group had impaired glucose gestational tolerance (IGGT) or GDM at the time of oral glucose tolerance test (OGTT). Moreover, ThyAb prevalence found in the women at increased risk of GDM (14.6%) was similar to that observed in healthy pregnant controls (12.5%). Nevertheless ThyAb frequency was higher in those GDM risk women with family history of diabetes (30.7%).
孕期抗甲状腺自身抗体（ThyAb）的存在与产后甲状腺炎（PPT）的发病风险密切相关，且这种风险在患有胰岛素依赖型糖尿病（IDDM）的孕妇中会增加。妊娠期糖尿病（GDM）被定义为在孕期开始出现或首次被诊断出的严重程度各异的碳水化合物不耐受。GDM被认为是1型和2型糖尿病的一个风险因素，并且已发现多种非器官特异性自身抗体与GDM相关，尽管关于GDM与甲状腺自身免疫性之间关联的信息较少。在本研究中，对一组有较高GDM发病风险的41名孕妇以及一个健康对照组进行了口服葡萄糖耐量和ThyAb患病率的评估。我们的结果显示，在口服葡萄糖耐量试验（OGTT）时，22%的GDM风险组孕妇存在葡萄糖耐量受损（IGGT）或患有GDM。此外，在有较高GDM发病风险的女性中发现的ThyAb患病率（14.6%）与健康孕妇对照组中观察到的患病率（12.5%）相似。然而，在有糖尿病家族史的GDM风险女性中，ThyAb频率更高（30.7%）。
