González-Jiménez A, Fernández-Soto M L, Lobón-Hernández J A, López-Medina J A, Navarrete L, Escobar-Jiménez F
Endocrinology and Nutrition Service, University of Granada Hospital, Spain.
Ann Ist Super Sanita. 1997;33(3):437-9.
The aim of this study was to assess thyroid dysfunction and autoimmunity in pregnant insulin-dependent diabetes mellitus (IDDM) women during pregnancy and early post partum. Fifteen pregnant IDDM women and 77 healthy pregnant women were studied. Free T4, TSH, TPO-Ab and Tg-Ab were assayed during the first and third trimester of pregnancy and 3 months post partum. In IDDM women FT4 levels significantly decreased (p < 0.05) during third trimester and 3 months post partum and also TPO-Ab during third trimester (p < .01). 26% of IDDM and 4% of the controls presented post partum thyroid dysfunction. We recommend that prepregnant IDDM be screened for TPO-Ab. Those with a positive result would be followed with serial monitoring of free T4 and TSH levels during each trimester as well as during the post partum period.
本研究的目的是评估妊娠期间及产后早期胰岛素依赖型糖尿病（IDDM）孕妇的甲状腺功能障碍和自身免疫情况。对15名妊娠IDDM妇女和77名健康孕妇进行了研究。在妊娠的第一个和第三个月以及产后3个月检测游离T4、促甲状腺激素（TSH）、甲状腺过氧化物酶抗体（TPO-Ab）和甲状腺球蛋白抗体（Tg-Ab）。在IDDM妇女中，妊娠第三个月和产后3个月期间游离T4水平显著下降（p<0.05），妊娠第三个月期间TPO-Ab水平也显著下降（p<0.01）。26%的IDDM妇女和4%的对照组出现产后甲状腺功能障碍。我们建议对孕前IDDM妇女进行TPO-Ab筛查。检测结果呈阳性的妇女在妊娠各期以及产后期间应定期监测游离T4和TSH水平。
