Pandey M, Khatri A K, Dubey S S, Gautam A, Shukla V K
Department of Surgery, Banaras Hindu University, Varanasi, India.
Eur J Surg Oncol. 1998 Feb;24(1):43-6. doi: 10.1016/s0748-7983(98)80124-8.
The role of erythrocyte membrane stearic to oleic acid ratio (saturation index) as a marker of malignancy is still unclear, though an association has been found in colorectal carcinoma, bronchogenic carcinoma, leukaemia, lymphoma and in hepatic malignancies. This study aims to investigate the role of the saturation index in primary carcinoma of the gallbladder.
This paper describes the results of the stearic to oleic acid ratio determination in 26 subjects with either cholelithiasis or carcinoma of the gallbladder, also including a group of age- and sex-matched controls, using gas chromatography. This is the first report of the saturation index in carcinoma of the gallbladder.
A significantly lower saturation index was observed in patients with carcinoma of the gallbladder than with cholelithiasis (t = 2.19, P = 0.043, T = 47, P < 0.05, Wilcoxon P < 0.001, F = 2192.23, P < 0.001; 95% CI 18.45-30.44) and controls (t = 2.5, P = 0.024, T = 36, P < 0.05, F = 10904.11, P < 0.001, Wilcoxon P < 0.001; 95% CI 52.42-63.39). Among the carcinoma patients a further lowering was noted in stage IV disease compared with stage III (T = 6, P < 0.05).
These changes are probably due to a marked increase in oleic acid content at the expense of stearic acid. This lowering of the saturation index in carcinoma of the gallbladder is similar to that observed previously in the other malignancies.
红细胞膜硬脂酸与油酸比率（饱和指数）作为恶性肿瘤标志物的作用仍不明确，尽管在结直肠癌、支气管癌、白血病、淋巴瘤及肝脏恶性肿瘤中已发现其存在关联。本研究旨在探讨饱和指数在胆囊原发性癌中的作用。
本文描述了采用气相色谱法测定26例患有胆结石或胆囊癌的受试者以及一组年龄和性别匹配的对照组的硬脂酸与油酸比率的结果。这是关于胆囊癌中饱和指数的首次报告。
与胆结石患者（t = 2.19，P = 0.043，T = 47，P < 0.05，Wilcoxon P < 0.001，F = 2192.23，P < 0.001；95%可信区间18.45 - 30.44）及对照组（t = 2.5，P = 0.024，T = 36，P < 0.05，F = 10904.11，P < 0.001，Wilcoxon P < 0.001；95%可信区间52.42 - 63.39）相比，胆囊癌患者的饱和指数显著降低。在癌症患者中，与III期相比，IV期疾病的饱和指数进一步降低（T = 6，P < 0.05）。
这些变化可能是由于油酸含量显著增加，以硬脂酸为代价。胆囊癌中饱和指数的降低与先前在其他恶性肿瘤中观察到的情况相似。
