胆囊原发性癌患者的红细胞膜脂肪酸谱

Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder.

作者信息

Pandey M, Khatri A K, Dubey S S, Gautam A, Shukla V K

机构信息

Department of Surgery, Banaras Hindu University, Varanasi, India.

出版信息

J Surg Oncol. 1995 May;59(1):31-4. doi: 10.1002/jso.2930590109.

DOI:10.1002/jso.2930590109

PMID:7745974

Abstract

Erythrocyte fatty acids were determined in patients with gall stones and carcinoma of the gallbladder. Significantly low levels of myristic acid (P < 0.01) and stearic acid (P < 0.001) and significantly high levels of palmitoleic acid (P < 0.05) and oleic acid (P < 0.01) were observed in cancer patients. Arachidonic and linolenic acid were significantly high in gallstone patients, but there was no significant difference in the lauric acid and palmitic acid levels. Thus an altered lipid metabolism in cancer patients suggest existence of a possible association between gallstones, fatty acids, and carcinoma of the gallbladder.

摘要

对胆结石患者和胆囊癌患者的红细胞脂肪酸进行了测定。在癌症患者中观察到肉豆蔻酸水平显著降低（P < 0.01），硬脂酸水平显著降低（P < 0.001），而棕榈油酸水平显著升高（P < 0.05），油酸水平显著升高（P < 0.01）。胆结石患者的花生四烯酸和亚麻酸水平显著升高，但月桂酸和棕榈酸水平无显著差异。因此，癌症患者脂质代谢的改变表明胆结石、脂肪酸和胆囊癌之间可能存在关联。