Balakrishnan S, Pandhi P
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Methods Find Exp Clin Pharmacol. 1997 Dec;19(10):693-7.
Anticonvulsant effects of phenytoin (PHT) and valproate (VPA) were studied alone and in combination with nimodipine (NMD) against maximal electroshock (MES)-induced seizures in rats. PHT and VPA induce cognitive deficit in terms of long-term memory loss. The effect of NMD on the cognitive deficit induced by PHT and VPA was studied through the step-through passive avoidance test (PAT). It was seen that there was a potentiation of antielectroshock effect of PHT and VPA when NMD at a dose of 4 mg/kg was combined with PHT or VPA. NMD reversed the long-term memory loss induced by PHT and VPA in the PAT.
