Matsuzawa S, Suzuki T, Misawa M
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Eur J Pharmacol. 1998 Jan 12;341(2-3):127-30. doi: 10.1016/s0014-2999(97)01456-8.
The purpose of the present study was to establish ethanol-induced place preference under conditioned fear stress (exposure to an environment paired previously with electric foot shock) in rats by using the conditioned place preference paradigm. The administration of ethanol (300 mg/kg, i.p.) with conditioned fear stress, but not without conditioned fear stress, induced a marked and significant place preference. Furthermore, additional exposure to conditioned fear stress immediately before the post-conditioning test further enhanced the development of ethanol-induced place preference. These results suggest that psychological stress may play an important role in the development of ethanol-induced place preference, and the present method may be useful for studying the mechanism of the rewarding effect of ethanol.
本研究的目的是通过条件性位置偏爱范式，在条件性恐惧应激（暴露于先前与足部电击配对的环境）下，在大鼠中建立乙醇诱导的位置偏爱。在有条件性恐惧应激的情况下给予乙醇（300mg/kg，腹腔注射），而非在没有条件性恐惧应激的情况下给予乙醇，可诱导出显著的位置偏爱。此外，在条件化后测试前立即再次暴露于条件性恐惧应激，进一步增强了乙醇诱导的位置偏爱的形成。这些结果表明，心理应激可能在乙醇诱导的位置偏爱的形成中起重要作用，并且本方法可能有助于研究乙醇奖赏效应的机制。
