Department of Diagnostic Radiology; Yale Stress Center; Yale University School of Medicine, New Haven, CT, USA.
Departments of Psychiatry and Neuroscience; Yale Stress Center; Yale University School of Medicine, New Haven, CT, USA.
Trends Neurosci. 2018 Nov;41(11):853-868. doi: 10.1016/j.tins.2018.08.005. Epub 2018 Aug 28.
The biological stress response of the body forms one of the foundations of adaptive behavior, including promoting (and impairing) different forms of memory. This response transcends stressful experiences and underlies reactions to challenges and even reinforcers such as addictive substances. Nevertheless, drug-induced stress responses are rarely incorporated into models of addiction. We propose here that drug-induced stress responses (particularly glucocorticoids) play a crucial role in addictive behavior by modulating the formation of memories for substance-use experiences. We review the contributions of amygdala-, striatum-, and hippocampus-based memory systems to addiction, and reveal common effects of addictive drugs and acute stress on these different memories. We suggest that the contributions of drug-induced stress responses to memory may provide insights into the mechanisms driving addictive behavior.
机体的生物应激反应是适应行为的基础之一，包括促进（和损害）不同形式的记忆。这种反应超越了应激体验，是对挑战甚至强化物（如成瘾物质）反应的基础。然而，药物引起的应激反应很少被纳入成瘾模型。我们在此提出，药物引起的应激反应（特别是糖皮质激素）通过调节物质使用体验记忆的形成，在成瘾行为中起着关键作用。我们回顾了基于杏仁核、纹状体和海马体的记忆系统对成瘾的贡献，并揭示了成瘾药物和急性应激对这些不同记忆的共同影响。我们认为，药物引起的应激反应对记忆的贡献可能为理解驱动成瘾行为的机制提供线索。
