Rompré P P, Boye S M, Moisan J
Centre de recherche de l'Hôpital Sacré-Coeur, Département de Psychiatrie, Université de Montréal, Québec, Canada.
Eur J Pharmacol. 1998 Jan 12;341(2-3):169-72. doi: 10.1016/s0014-2999(97)01475-1.
The effects of medial prefrontal cortex microinjections of 3 nmol/0.5 microl of neurotensin-(1-13), the inactive fragment neurotensin-(1-8), or vehicle on the firing rate of midbrain dopamine neurons were studied in anesthetized rats. Twelve of 19 cells tested with neurotensin-(1-13) showed an average 20-25% increase in firing rate between 10 and 20 min after the injection. This effect was not mimicked by neurotensin-(1-8) (9 cells), nor by a control injection (10 cells) suggesting that it is mediated by high-affinity neurotensin receptors. These results suggest that activation of neurotensin receptors in the medial prefrontal cortex can modulate neural activity of a subpopulation of midbrain dopamine neurons.
在麻醉大鼠中，研究了向内侧前额叶皮质微量注射3 nmol/0.5微升的神经降压素-（1-13）、无活性片段神经降压素-（1-8）或溶剂对中脑多巴胺能神经元放电频率的影响。用神经降压素-（1-13）测试的19个细胞中有12个在注射后10至20分钟内放电频率平均增加了20-25%。神经降压素-（1-8）（9个细胞）和对照注射（10个细胞）均未模拟出这种效应，这表明它是由高亲和力神经降压素受体介导的。这些结果表明，内侧前额叶皮质中神经降压素受体的激活可以调节中脑多巴胺能神经元亚群的神经活动。
