Fatigati M D, Anderson R M, Rompré P
Centre de recherche de Fernand-Seguin, Département de Psychiatrie, Hôpital Louis-H. Lafontaine, Université de Montréal, Québec, H1N 3V2, Montréal, Canada.
Brain Res. 2000 Sep 8;876(1-2):196-200. doi: 10.1016/s0006-8993(00)02654-8.
Effects of prefrontal cortex microinjections of 0.3 and 3 nmol/0.5 microl of neurotensin-(8-13) on the firing rate of midbrain dopamine and non-dopamine cells were studied in urethane-anesthetized rats. Neurotensin produced an increase in firing in 14 of 26 dopamine cells tested, an effect that peaked between 15 and 20 min after the injection at both doses. On the other hand, a majority of non-dopamine cells (7/10) tested with the higher dose of neurotensin showed a statistically significant decrease in firing when compared to saline, an effect that also peaked between 15 and 20 min. These results show that prefrontal cortex neurotensin can modulate both dopamine and non-dopamine neurotransmission in the ventral midbrain.
在乌拉坦麻醉的大鼠中，研究了向额叶前皮质微量注射0.3和3 nmol/0.5微升的神经降压素-(8-13)对中脑多巴胺能和非多巴胺能细胞放电频率的影响。在26个受试多巴胺能细胞中，有14个细胞在注射神经降压素后放电增加，两种剂量下该效应均在注射后15至20分钟达到峰值。另一方面，用较高剂量神经降压素测试的大多数非多巴胺能细胞（7/10）与注射生理盐水相比，放电有统计学意义的减少，该效应也在15至20分钟达到峰值。这些结果表明，额叶前皮质神经降压素可调节腹侧中脑的多巴胺能和非多巴胺能神经传递。
