Noyan A, Anarat A, Anarat R, Noyan T
Department of Pediatric Nephrology, Cukurova University School of Medicine, Adana, Turkey.
Pediatr Nephrol. 1998 Feb;12(2):153-6. doi: 10.1007/s004670050428.
The purpose of this study was to investigate the acute changes in endothelin (ET) levels immediately after hemodialysis and to determine whether these changes vary with the use of different membranes and hemodialysis solutions. Ten children were included in the study. Three different hemodialysis sessions were performed on all patients: session 1, acetate-based dialysate and polycarbonate membrane; session 2, bicarbonate-based dialysate and polycarbonate membrane; session 3, acetate-based dialysate and polysulfone membrane. In all cases blood samples were obtained before and after dialysis. Pre- and post-hemodialysis ET levels of the patients with acetate-based dialysate and polycarbonate membrane were 33.68 +/- 11.51 pg/ml and 28.27 +/- 12.85 pg/ml, respectively. The fall in ET levels after this session was statistically significant (P = 0.015). We did not observe a statistically significant change in ET levels in the other sessions. Post-dialysis mean arterial pressure values were significantly lower than the pre-dialysis values in all three dialysis sessions (P < 0.01). A positive correlation was observed between plasma ET levels and blood urea nitrogen and serum potassium; a negative correlation was observed between plasma ET levels and hematocrit.
本研究的目的是调查血液透析后即刻内皮素（ET）水平的急性变化，并确定这些变化是否因使用不同的透析膜和血液透析液而有所不同。本研究纳入了10名儿童。对所有患者进行了三种不同的血液透析疗程：疗程1，使用醋酸盐透析液和聚碳酸酯膜；疗程2，使用碳酸氢盐透析液和聚碳酸酯膜；疗程3，使用醋酸盐透析液和聚砜膜。在所有情况下，均在透析前后采集血样。使用醋酸盐透析液和聚碳酸酯膜的患者透析前和透析后ET水平分别为33.68±11.51 pg/ml和28.27±12.85 pg/ml。该疗程后ET水平的下降具有统计学意义（P = 0.015）。我们在其他疗程中未观察到ET水平有统计学意义的变化。在所有三个透析疗程中，透析后平均动脉压值均显著低于透析前值（P < 0.01）。观察到血浆ET水平与血尿素氮和血清钾之间呈正相关；血浆ET水平与血细胞比容之间呈负相关。
