Lin S Y, Chen L Q, Wang Y H
Division of Nephrology, Huashan Hospital, Shanghai Medical University.
Zhonghua Nei Ke Za Zhi. 1991 Feb;30(2):73-5, 124.
In order to study the mechanism of plasma ET increment in CRF patients, we investigated 20 endothelin (CRF) patients undergone hemoultrafiltration for 90 min followed by hemodialysis, and 12 patients subjected to single hemodialysis. The results revealed that 90 min's ultrafiltration along with 2500 ml fluid extraction brought about a significant decrease in plasma ET (from 1132 to 753 pg/ml, P less than 0.05), while the hemodialysis without water extraction of a same period resulted no significant change. In the meantime, the BUN in the ultrafiltration group showed no prominent change. But the hemodialysis group presented a significant decrease (from 34.6 to 22.5 mmol/L P less than 0.05), which showed that the ET falling had no significant relevance to the metabolic products extraction. In the followed 120 min's hemodialysis, ET level in the two groups decreased in a different extend. Therefore, the research suggested that decreased extracellular volume via ultrafiltration can lead to the discretion of ET level.
为研究慢性肾功能衰竭（CRF）患者血浆内皮素（ET）升高的机制，我们对20例接受90分钟血液滤过继之血液透析的CRF患者及12例单纯接受血液透析的患者进行了研究。结果显示，90分钟的超滤伴2500ml液体清除使血浆ET显著下降（从1132降至753pg/ml，P<0.05），而同期无液体清除的血液透析则无显著变化。同时，超滤组的尿素氮（BUN）无明显变化。但血液透析组BUN显著下降（从34.6降至22.5mmol/L，P<0.05），这表明ET的下降与代谢产物的清除无显著相关性。在随后的120分钟血液透析中，两组ET水平以不同程度下降。因此，该研究提示，通过超滤减少细胞外液量可导致ET水平的变化。
