Davanzo P A, Belin T R, Widawski M H, King B H
University of California at Los Angeles, USA.
Am J Ment Retard. 1998 Mar;102(5):427-37. doi: 10.1352/0895-8017(1998)102<0427:ptoaas>2.0.co;2.
An open, prospective assessment of the treatment of severe aggression and self-injurious behavior (SIB) with paroxetine, a serotonin re-uptake inhibitor, in 15 institutionalized persons with mental retardation was undertaken. Frequency and severity of aggression and SIB were charted by trained staff members. Only aggression severity was reduced over the entire 4-month follow-up period. Within the limits of an open trial, this effect was significant at one month but did not remain significant subsequently. The apparent diminution of effectiveness after 4 weeks of treatment may suggest adaptive changes warranting further study.
对15名机构收容的智力障碍者使用5-羟色胺再摄取抑制剂帕罗西汀治疗严重攻击行为和自我伤害行为（SIB）进行了一项开放性前瞻性评估。攻击行为和SIB的频率及严重程度由经过培训的工作人员记录。在整个4个月的随访期内，仅攻击行为的严重程度有所降低。在开放试验的范围内，这种效果在1个月时显著，但随后不再显著。治疗4周后效果明显减弱，这可能表明存在适应性变化，值得进一步研究。
