Branford D, Bhaumik S, Naik B
Southern Derbyshire Mental Health Trust, Derby, England.
J Intellect Disabil Res. 1998 Aug;42 ( Pt 4):301-6. doi: 10.1046/j.1365-2788.1998.00144.x.
A retrospective case-note analysis was undertaken of 37 adults with intellectual disability who lived in Leicestershire, England. The subjects were prescribed one of two selective serotonin re-uptake inhibitor (SSRI) antidepressants, i.e. fluoxetine or paroxetine, for perseverative and maladaptive behaviours. The SSRIs proved to be of no benefit for 15 subjects (40%) and led to a deterioration in a further nine cases (25%). However, some reduction of perseverative and maladaptive behaviours was achieved in 13 cases (35%). There was no difference in the responses to fluoxetine or paroxetine.
对居住在英国莱斯特郡的37名成年智障患者进行了一项回顾性病例记录分析。这些受试者被开了两种选择性5-羟色胺再摄取抑制剂（SSRI）抗抑郁药中的一种，即氟西汀或帕罗西汀，用于治疗持续性和适应不良行为。结果证明，SSRI对15名受试者（40%）没有益处，另外9例（25%）病情恶化。然而，13例（35%）患者的持续性和适应不良行为有所减少。氟西汀和帕罗西汀的疗效没有差异。
