Karcioglu Z A, El-Yazigi A, Jabak M H, Choudhury A H, Ahmed W S
King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
Ophthalmology. 1998 Apr;105(4):658-61. doi: 10.1016/S0161-6420(98)94020-9.
To determine the effectiveness of single-dose oral azithromycin in the treatment of Chlamydia trachomatis through monitoring of tear and serum levels.
Nonrandomized, clinical trial.
Fourteen school-age children with active trachoma (one failed to complete the study).
A single dose of azithromycin (20 mg/kg) was administered orally to 14 patients, and tear and serum levels were determined with high-performance liquid chromatography at 12, 24, 48, 72, 96, 120, and 144 hours after administration.
Azithromycin levels in tears and serum.
Peak levels of 1.53 microg/ml (standard deviation [SD] +/- 0.94) and 0.15 microg/ml (SD +/- 0.04) were obtained at 12 hours in both tears and serum, gradually decreasing over 144 hours. All patients were disease-free by 6 months.
Levels of azithromycin in patients with trachoma were found to be within minimum inhibitory concentration range for Chlamydia trachomatis (0.03-0.25 microg/ml) throughout the monitored period of 6 days.
通过监测泪液和血清水平来确定单剂量口服阿奇霉素治疗沙眼衣原体感染的有效性。
非随机临床试验。
14名患有活动性沙眼的学龄儿童（1名未完成研究）。
对14名患者口服单剂量阿奇霉素（20mg/kg），并在给药后12、24、48、72、96、120和144小时用高效液相色谱法测定泪液和血清水平。
泪液和血清中的阿奇霉素水平。
泪液和血清在12小时时的峰值水平分别为1.53μg/ml（标准差[SD]±0.94）和0.15μg/ml（SD±0.04），在144小时内逐渐下降。所有患者在6个月时均无疾病。
在6天的监测期内，沙眼患者体内阿奇霉素水平在沙眼衣原体的最低抑菌浓度范围内（0.03 - 0.25μg/ml）。
